Enzyme activity maintenance in packed-bed reactors via continuous enzyme addition

Journal Article · Wed Dec 31 23:00:00 EST 1980 · Biotechnol. Bioeng.; (United States)

DOI:https://doi.org/10.1002/bit.260230105· OSTI ID:6742296

Verhoff, F H; Schlager, S T

An operational scheme for using immobilized enzymes in packed-bed reactors that permits operation at a constant throughput rate and constant product quality is described. The scheme uses columns operated in series with continuous enzyme volume in the column system. Operation of columns in series is compared to operation where the flow rate is decreased to compensate for a loss of enzyme activity for both zero- and first-order decay. The analyses indicated that columns in series resulted in better enzyme utilization but larger reactor volumes than parallel reactors with decreasing flow rate.

• Research Organization: Dept of Chemical Engineering, West Virginia Univ, Morgantown, West Virginia 26506
• OSTI ID: 6742296
• Journal Information: Biotechnol. Bioeng.; (United States), Journal Name: Biotechnol. Bioeng.; (United States) Vol. 23:1; ISSN BIBIA
• Country of Publication: United States
• Language: English

Related Subjects

09 BIOMASS FUELS
140504* -- Solar Energy Conversion-- Biomass Production & Conversion-- (-1989)
CHEMICAL REACTION KINETICS
CHEMICAL REACTORS
EXTRACTION APPARATUSES
EXTRACTION COLUMNS
IMMOBILIZED ENZYMES
KINETICS
MAINTENANCE
MATHEMATICAL MODELS
OPERATION
OPTIMIZATION
PACKED BED
REACTION KINETICS
SEPARATION EQUIPMENT