Myocardial perfusion abnormalities in asymptomatic patients with systemic lupus erythematosus

Journal Article · Wed Aug 01 04:00:00 EDT 1984 · Am. J. Med.; (United States)

DOI:https://doi.org/10.1016/0002-9343(84)90704-6· OSTI ID:6741157

Hosenpud, J D; Montanaro, A; Hart, M V; Haines, J E; Specht, H D; Bennett, R M; Kloster, F E

Accelerated coronary artery disease and myocardial infarction in young patients with systemic lupus erythematosus is well documented; however, the prevalence of coronary involvement is unknown. Accordingly, 26 patients with systemic lupus were selected irrespective of previous cardiac history to undergo exercise thallium-201 cardiac scintigraphy. Segmental perfusion abnormalities were present in 10 of the 26 studies (38.5 percent). Five patients had reversible defects suggesting ischemia, four patients had persistent defects consistent with scar, and one patient had both reversible and persistent defects in two areas. There was no correlation between positive thallium results and duration of disease, amount of corticosteroid treatment, major organ system involvement or age. Only a history of pericarditis appeared to be associated with positive thallium-201 results (p less than 0.05). It is concluded that segmental myocardial perfusion abnormalities are common in patients with systemic lupus erythematosus. Whether this reflects large-vessel coronary disease or small-vessel abnormalities remains to be determined.

• Research Organization: Department of Medicine, Oregon Health Sciences University, Portland
• OSTI ID: 6741157
• Journal Information: Am. J. Med.; (United States), Journal Name: Am. J. Med.; (United States) Vol. 77:2; ISSN AJMEA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BACTERIAL DISEASES
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEART
HEAVY NUCLEI
INFECTIOUS DISEASES
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUPUS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOGENESIS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SKIN DISEASES
THALLIUM 201
THALLIUM ISOTOPES
TUBERCULOSIS
VASCULAR DISEASES