Total half-body systemic irradiation for occult metastases in non-small cell lung cancer: an Eastern Cooperative Oncology group pilot report
There is a high probability for patients with locally advanced, unresectable, nonmetastatic, nonsmall-cell bronchogenic carcinoma (NSCBC) to harbor subclinical distant metastases at diagnosis. Approximately 30% will disseminate in the first three months and an additional 50% will disseminate before a year has elapsed. Twenty advanced nonmetastatic patients wtith NSCBC were treated with localized split-course chest irradiation (LCI) plus total body (upper and lower half-body) irradiation for occult metastases. Thirty equally advanced, nonmetastatic patients, who were treated with only localized split-course chest irradiation, were matched and served as a retrospective control group. Apparently, the median recurrence free survival, metastatic free interval, and median survival were significantly prolonged, and there was a decrease in the incidence of liver metastases in patients receiving HBI for occult metastases over the patients of the control group. Although elective HBI seems to delay the appearance of distant metastases, it did not prevent their occurrence, alter patterns of first relapse, or significantly improve the overall survival. Nevertheless, a therapeutic gain may have been achieved and is discussed. The incidence of radiation pneumonitis with 800 rad of UHBI corrected for lung transmission was 9%. A hypothesis and a rationale for a more effective combined modality therapy in these patients is given.
- Research Organization:
- Univ. of Rochester, New York
- OSTI ID:
- 6740980
- Journal Information:
- Cancer; (United States), Vol. 46:9
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BRONCHOPNEUMONIA
RADIOINDUCTION
FIBROSIS
FRACTIONATED IRRADIATION
COMPARATIVE EVALUATIONS
LUNGS
DELAYED RADIATION EFFECTS
METASTASES
RADIOTHERAPY
MYELITIS
PARTIAL BODY IRRADIATION
PNEUMONITIS
SIDE EFFECTS
SPINAL CORD
LIVER
NEOPLASMS
PATIENTS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
DISEASES
EXTERNAL IRRADIATION
GLANDS
IRRADIATION
MEDICINE
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PNEUMONIA
RADIATION EFFECTS
RADIOLOGY
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man