Arsenical and mercurial inhibition of tyrosine transport by the flounder intestine. [Pseudopleuronectes americanus]

Journal Article · Fri Jan 01 04:00:00 EST 1988 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398809531111· OSTI ID:6727488

Chauncey, B; Schmid, E C; Goldstein, L

The effects of mercurials and arsenicals on tyrosine absorption by the winter flounder Pseudopleuronectes americanus were studied using isolated intestinal strips. The mercurials mercuric chloride (HgCl/sub 2/), p-chloromercuriphenyl sulfonic acid (PCMBS), and phenylmercuric acetate (PMA) and the arsenicals oxophenylarsine and arsenamide were chosen for their different chemical properties. The transmural absorptive fluxes (mucosa to serosa, M ..-->.. S), were inhibited by mucosal additions of 0.1 mM HgCl/sub 2/ (64% inhibition), 1.0 mM PCMBS (41% inhibition), and 0.25 mM oxophenylarsine (48% inhibition). Tyrosine tissue accumulation was inhibited 68% by 0.1 mM HgCl/sub 2/, 42% by 1.0 mM PCMBS, and 62% by 0.25 mM oxophenylarsine. Serosal addition of 1.0 mM PCMBS inhibited M ..-->.. S flux by 45%. Transepithelial potential (TEP) was measured to monitor changes in ionic gradients across the epithelial membrane. Mucosal addition of 0.1 mM HgCl/sub 2/, and of 0.25 and 0.05 mM oxophenylarsine significantly changed the TEP. Serosal additions of 0.1 mM HgCl/sub 2/, 1.0 mM PCMBS, and 0.25 mM oxophenylarsine also altered the TEP significantly.

• Research Organization: Brown Univ., Providence, RI (USA)
• OSTI ID: 6727488
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 23:2; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
AQUATIC ORGANISMS
ARSENIC COMPOUNDS
BIOCHEMICAL REACTION KINETICS
BODY
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
FISHES
GASTROINTESTINAL TRACT
HYDROXY ACIDS
INHIBITION
INTESTINES
KINETICS
MERCURY COMPOUNDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
REACTION KINETICS
TOXICITY
TYROSINE
VERTEBRATES