Platelet kinetics and biodistribution in canine endotoxemia
Kinetics and magnitudes of changes in indium-labeled platelet biodistribution were studied in dogs given E. coli endotoxin. Marked, reversible, dose-dependent shifts of platelets from blood to lung and apparently irreversible shifts to liver were demonstrated. These were contemporaneous with alterations in blood gases and in pulmonary and systemic hemodynamics. Morphologic studies revealed atelectasis, sequestration of leukocytes and platelets in the lungs, and mild interstitial pulmonary edema. This study provides in vivo quantification of labeled platelet response to a specific stimulus, and illustrates a method that could be applied to more extensive study of blood element participation in acute lung injury.
- Research Organization:
- Yale Univ. School of Medicine, New Haven, CT
- OSTI ID:
- 6723846
- Journal Information:
- Invest. Radiol.; (United States), Vol. 18:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BLOOD PLATELETS
BIOLOGICAL ACCUMULATION
ENDOTOXINS
BIOLOGICAL EFFECTS
LUNGS
PATHOLOGICAL CHANGES
BLOOD
DOGS
ESCHERICHIA COLI
INDIUM ISOTOPES
LABELLED POOL TECHNIQUES
SENSITIVITY
TISSUE DISTRIBUTION
TRACER TECHNIQUES
ANIMALS
ANTIGENS
BACTERIA
BIOLOGICAL MATERIALS
BLOOD CELLS
BODY
BODY FLUIDS
DISTRIBUTION
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
MICROORGANISMS
ORGANS
RESPIRATORY SYSTEM
TOXIC MATERIALS
TOXINS
VERTEBRATES
550901* - Pathology- Tracer Techniques