Mucociliary clearance from the lungs of rabbits following single and intermittent exposures to ozone
This study examined the effects of ozone (O/sub 3/) inhalation on mucociliary clearance from the tracheobronchial tree. Rabbits were exposed for 2 h at 0.1, 0.25, and 0.6 ppm or for 2 h/d for 14 consecutive days at 0.25 and 0.6 ppm. Clearance was assessed by measuring the retention of radioactivity tagged, inert tracer particles inhaled immediately after the single 2-h exposure, or 24 h after 2, 7, or 14 of the daily exposures. Single exposures resulted in a concentration-related trend toward retarded particle clearance, with a statistically significant difference occurring after exposure to 0.6 ppm. Intermittent exposures produced no significant change in clearance rate, although there was a suggestion of retarded clearance at early time points at both 0.25 and 0.6 ppm.
- Research Organization:
- Univ. Medical Center, New York, NY
- OSTI ID:
- 6723786
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 20:1-2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
OZONE
TOXICITY
PARTICULATES
LUNG CLEARANCE
RETENTION
DOSE-RESPONSE RELATIONSHIPS
INHALATION
RABBITS
TIME DEPENDENCE
TRACER TECHNIQUES
ANIMALS
CLEARANCE
EXCRETION
INTAKE
ISOTOPE APPLICATIONS
MAMMALS
PARTICLES
VERTEBRATES
500200* - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)
560300 - Chemicals Metabolism & Toxicology
551001 - Physiological Systems- Tracer Techniques