Second cancers after radiotherapy and chemotherapy for early stages of Hodgkin's disease

Journal Article · Tue Nov 01 04:00:00 EST 1983 · J. Natl. Cancer Inst.; (United States)

OSTI ID:6723131

Henry-Amar, M

In a population of 334 patients treated for Hodgkin's disease by the European Organization for Research and Treatment of Cancer between 1964 and 1971, 21 patients with second primary cancers (SC) were observed: 4 patients with acute leukemias, 3 with non-Hodgkin's lymphomas, and 14 with solid tumors. Time to SC ranged from 2 to 16 years after initial treatment. The relative risk (RR) of acute leukemia for the patients with Hodgkin's disease as compared to the general population was 40. The RR of leukemia in patients treated by polychemotherapy--mechlorethamine, vincristine, procarbazine, and prednisone--for relapse was 300. However, the RR of leukemia for those patients who did not experience a relapse was 14 (not significant). The RR of other SC in the overall group was 3.76. For patients whose relapses were treated by polychemotherapy the RR of SC, leukemia excepted, was 26, whereas for patients not treated by polychemotherapy for relapse the RR was slightly increased. The cumulative proportions of acute leukemia at 10 years were 0.7% in the ''no-relapse'' group and 2.7% in the polychemotherapy group. The cumulative proportions of other SC at 10 years was 1.3% in the no-relapse group, 7.2% in the group of patients not treated by polychemotherapy after relapse, and 8.4% in the polychemotherapy group. The first important risk factor for developing an SC was polychemotherapy, and the second was age over 40 years. These data suggest that combination chemotherapy may be responsible for both acute leukemias and other SC.

• Research Organization: Unite de Recherches Statistiques--INSERM, Villejuif, France
• OSTI ID: 6723131
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 71:5; ISSN JNCIA
• Country of Publication: United States
• Language: English

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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHEMOTHERAPY
DELAYED RADIATION EFFECTS
DISEASES
HEMIC DISEASES
HODGKINS DISEASE
LEUKEMIA
LYMPHOMAS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY