The lethal interaction of x ray and penicillin induced lesions following x-irradiation of Escherichia coli B/r in the presence of hypoxic cell sensitizers

Journal Article · Mon Mar 01 00:00:00 EST 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90659-9· OSTI ID:6722985

Gillies, N E; Obioha, F I

When Escherichia coli B/r were x-irradiated under anoxia in the presence of different electron-affinic sensitizers and then incubated in broth containing penicillin (at a concentration that did not kill unirradiated cells) additional killing of the bacteria occurred provided the sensitizers were of relatively high lipophilicity. The overall effect was to increase the efficiency of these sensitizers. It is concluded that sensitizer-dependent latent radiation lesions(s) are produced in membrane components of the cell envelope that interact with damage caused by penicillin in the peptidoglycan layer and this causes the additional lethality.

• Research Organization: Middlesex Hospital Medical School, London, England
• OSTI ID: 6722985
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 8:3/4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CELL MEMBRANES
BIOLOGICAL RADIATION EFFECTS
PENICILLIN
CELL KILLING
RADIOSENSITIZERS
RADIOSENSITIVITY EFFECTS
X RADIATION
SYNERGISM
ANOXIA
ESCHERICHIA COLI
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BACTERIA
BIOLOGICAL EFFECTS
CELL CONSTITUENTS
DRUGS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MEMBRANES
MICROORGANISMS
RADIATION EFFECTS
RADIATIONS
560131* - Radiation Effects on Microorganisms- Basic Studies- (-1987)