Percutaneous absorption of selenium sulfide

Journal Article · Wed Jan 01 00:00:00 EST 1986 · J. Environ. Sci. Health, Part A; (United States)

DOI:https://doi.org/10.1080/10934528609375313· OSTI ID:6721585

Farley, J; Skelly, E M; Weber, C B

The purpose of this study was to determine selenium levels in the urine of Tinea patients before and after overnight application of a 2.5% selenium sulfide lotion. Selenium was measured by atomic absorption spectroscopy (AAS). Hydride generation and carbon rod atomization were studied. It was concluded from this study that selenium is absorbed through intact skin. Selenium is then excreted, at least partially, in urine, for at least a week following treatment. The data show that absorption and excretion of selenium vary on an individual basis. Selenium levels in urine following a single application of selenium sulfide lotion do not indicate that toxic amounts of selenium are being absorbed. Repeated treatments with SeS/sub 2/ result in selenium concentrations in urine which are significantly higher than normal. Significant matrix effects are observed in the carbon rod atomization of urine samples for selenium determinations, even in the presence of a matrix modifier such as nickel. The method of standard additions is required to obtain accurate results in the direct determination of selenium in urine by carbon rod AAS.

• Research Organization: Military Academy, West Point, NY
• OSTI ID: 6721585
• Journal Information: J. Environ. Sci. Health, Part A; (United States), Vol. A21:6
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
SELENIUM
BIOLOGICAL AVAILABILITY
SKIN ABSORPTION
ABSORPTION SPECTROSCOPY
EXCRETION
PATIENTS
SKIN DISEASES
URINE
VARIATIONS
ABSORPTION
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CLEARANCE
DISEASES
ELEMENTS
MATERIALS
SEMIMETALS
SPECTROSCOPY
UPTAKE
WASTES
550500* - Metabolism