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Results of biopsy after early stage prostatic cancer treatment by implantation of /sup 125/I seeds

Journal Article · · J. Urol.; (United States)
OSTI ID:6719992
; ; ; ; ;

Seventy-seven patients have been treated for clinically early stage carcinoma of the prostate, 9 stage A2, 63 stage B and 5 stage C, with direct implantation of /sup 125/I seeds into the prostate and pelvic lymphadenectomy. It is estimated that a minimum dose of 15,000 rad but a maximum dose of 35,000 rad is delivered to the prostate over several months. Of the 77 patients, 14 (18%) had metastatic disease in the pelvic lymph nodes. In 22 cases perineal needle biopsy was done 12 to 18 months after treatment and in 3 cases a second biopsy was performed after 2 to 3 years. Persistent tumor was present in 11 biopsies. Cytological changes were observed in 8 of these, primarily cytoplasmic vacuolation and nuclear pyknosis. There seemed to be no relationship between grade and stage of disease and histological evidence of persistence of tumor after radiation. One patient with persistent tumor in the postoperative biopsy has shown progression of disease after 2 years and another with a negative biopsy has a bony metastasis. The remaining 10 patients with persistent tumor have shown no sign of progression of disease during a 2 to 4-year interval.

Research Organization:
Yale Univ., New Haven, CT
OSTI ID:
6719992
Journal Information:
J. Urol.; (United States), Journal Name: J. Urol.; (United States) Vol. 121:3; ISSN JOURA
Country of Publication:
United States
Language:
English

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Related Subjects

550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
560161* -- Radionuclide Effects
Kinetics
& Toxicology-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOPSY
BODY
BODY AREAS
CARCINOMAS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
HISTOLOGY
IMPLANTS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
LYMPH NODES
LYMPHATIC SYSTEM
MALE GENITALS
MEDICINE
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PELVIS
PROSTATE
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
THERAPY