Foam flotation enrichment of enantiomers

Journal Article · Thu Dec 01 00:00:00 EST 1994 · Analytical Chemistry (Washington); (United States)

DOI:https://doi.org/10.1021/ac00095a025· OSTI ID:6718673

Armstrong, D W; Zhou, E Y; Chen, S; Le, K; Tang, Y ^[1]

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1. Univ. of Missouri, Rolla, MO (United States)

Adsorptive bubble separation methods are known to be useful for processing large amounts of material at a relatively low cost. These techniques have been used to enrich components from both heterogeneous and homogeneous solutions. There is a need for economical process-scale enantiomeric separations. Thus far there has been little evidence to support the feasibility of 2using an adsorptive bubble process to enrich enantiomers. We demonstrate that foam-forming chiral collectors can be used in conjunction with an inexpensive glass device to enantiomerically enrich some pharmaceutically important compounds as well as derivatized and underivatized amino acids. Factors that appeared to affect this water-based separation include the following: (a) column length, (b) column geometry and packing, (c) gas flow rate, (d) concentration of the collector and the racemate, (e) nature of the collector, (f) temperature, (g) pH, (h) reflux time, (i) foam dryness, and (j) the presence of other materials in the sample (e.g., miscible organic solvents, salts, etc.). The chiral collectors used in this study are known to be able to associate with analytes via ligand exchange interactions, hydrophobic inclusion complexation, and hydrogen-bonding interactions among others. 28 refs., 5 figs., 5 tabs.

• DOE Contract Number: FG02-88ER13819
• OSTI ID: 6718673
• Journal Information: Analytical Chemistry (Washington); (United States), Vol. 66:23; ISSN 0003-2700
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
ENANTIOMORPHS
DERIVATIZATION
FLOTATION
SEPARATION PROCESSES
TEMPERATURE DEPENDENCE
ADSORPTION
AMINO ACIDS
ANTIBIOTICS
BUBBLES
COMPILED DATA
DRUGS
LIQUID COLUMN CHROMATOGRAPHY
PH VALUE
WATER
ANTI-INFECTIVE AGENTS
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
CHROMATOGRAPHY
DATA
HYDROGEN COMPOUNDS
INFORMATION
ISOMERS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
SORPTION
400105* - Separation Procedures
400201 - Chemical & Physicochemical Properties