Cf-252 brain implantation for malignant glioma: Experience of the University of Kentucky, Lexington

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Nucl. Sci. Appl.; (United States)

OSTI ID:6718287

Chin, H W; Maruyama, Y; Yong, A B; Beach, J L; Tibbs, P A; Markesbery, W

Since 1980, --65 patients with hemispheric malignant gliomas have been treated in studies testing Cf-252 neutron brain implant therapy combined with whole/part brain radiotherapy to --6000 cGy. Methods, techniques, number of tubes implanted and the placement of tubes relative to the contrast enhanced edge of the tumor and brain imaging have evolved during this time. The patients receiving single tube implant had marked improvement in their performance status but a survival period of only --1 year. With the use of multiple tubes, survival results improved and was 63% at 12 months and continues at --30% at about 2 years. The advent of tumor staging using CT and MR scanning, multiple tube stereotaxic implants placed around the enhancing edge of the lesion and whole/part brain radiation may further improve local tumor control. Methods for the conduct of a therapeutic trial that could lead to more effective treatment of malignant tumors appear to be evolving.

• Research Organization: Radiation Therapy Oncology Center, Univ. of Kentucky Medical Center, Lexington, KY
• OSTI ID: 6718287
• Journal Information: Nucl. Sci. Appl.; (United States), Vol. 2:3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
GLIOMAS
CALIFORNIUM 252
THERAPEUTIC USES
NEUTRON THERAPY
COMPUTERIZED TOMOGRAPHY
IMAGE PROCESSING
KENTUCKY
MEDICAL ESTABLISHMENTS
PATIENTS
RADIATION SOURCE IMPLANTS
SURVIVAL TIME
TUBES
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
BODY
CALIFORNIUM ISOTOPES
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
EVEN-EVEN NUCLEI
FEDERAL REGION IV
HEAVY NUCLEI
IMPLANTS
ISOTOPES
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NORTH AMERICA
NUCLEAR MEDICINE
NUCLEI
ORGANS
PROCESSING
RADIATION SOURCES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
THERAPY
TOMOGRAPHY
USA
USES
YEARS LIVING RADIOISOTOPES
550603* - Medicine- External Radiation in Therapy- (1980-)
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)