Diffuse interstitial pulmonary fibrosis: pulmonary fibrosis in mice induced by treatment with butylated hydroxytoluene and oxygen

Journal Article · Mon Nov 30 23:00:00 EST 1981 · Am. J. Pathol.; (United States)

OSTI ID:6716008

Haschek, W M ^[1]; Brody, A R; Klein-Szanto, A J.P.; Witschi, H

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1. Oak Ridge National Lab., TN

It is proposed that the pulmonary fibrosis induced in mice by treatment with BHT and oxygen is a good experimental model for human pulmonary fibrosis. The mechanism of synergistic and additive effects of various agents on pulmonary injury and the epithelial mesenchymal interactions occurring during the early and late phases of lung repair could be studied. This model could be used for study of the effects of various concentrations of oxygen on diffusely damaged lung and assessment of the efficacy of drugs in preventing or resolving excessive collagen accumulation in lung. In addition, the relationship between pulmonary fibrosis and emphysema could be studied.

• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6716008
• Journal Information: Am. J. Pathol.; (United States), Journal Name: Am. J. Pathol.; (United States) Vol. 105:3; ISSN AJPAA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
AMINES
AMINO ACIDS
ANIMALS
AROMATICS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BODY
CARBOXYLIC ACIDS
CELL PROLIFERATION
CRESOLS
ELEMENTS
FIBROSIS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY ACIDS
HYDROXY COMPOUNDS
HYDROXYPROLINE
LUNGS
MAMMALS
MICE
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN
PATHOLOGICAL CHANGES
PHENOLS
PNEUMONITIS
PYRROLES
PYRROLIDINES
RESPIRATORY SYSTEM
RODENTS
SYNERGISM
VERTEBRATES