Natural cell mediated cytotoxicity in mice treated with total lymphoid irradiation (TLI)
Journal Article
·
· Cell. Immunol.; (United States)
Fractionated total lymphoid irradiation (TLI) of adult (BALB/c X C57BL/6)F/sub 1/ mice resulted in transiently augmented natural killer (NK) and natural cytotoxic (NC) cell activities. Thus, 1 day after completion of TLI, NK and NC activities in the spleens of treated mice were lower than controls but values increased and reached a maximum level of 23- to 190-fold above control at 6 days after irradiation, returning to normal levels 9 days later. Cytotoxicity was enhanced after removal of the plastic adherent population.No cytotoxicity was observed against P 815 target cells, which are sensitive to activated macrophages but not to NK. The significance of this modulation of natural cell-mediated cytotoxicity following TLI is discussed.
- Research Organization:
- Hebrew Univ. of Jerusalem, Israel
- OSTI ID:
- 6713995
- Journal Information:
- Cell. Immunol.; (United States), Journal Name: Cell. Immunol.; (United States) Vol. 70:1; ISSN CLIMB
- Country of Publication:
- United States
- Language:
- English
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· JNCI, J. Natl. Cancer Inst.; (United States)
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Natural cytolytic activity in mice with natural or induced cellular defects. I. Differential ability of in vitro interleukin-2 addition to augment natural cytolytic function
Journal Article
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· Cell. Immunol.; (United States)
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OSTI ID:5005693
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BODY
CELL KILLING
CONNECTIVE TISSUE CELLS
FRACTIONATED IRRADIATION
IMMUNE REACTIONS
IRRADIATION
LYMPH NODES
LYMPHATIC SYSTEM
MACROPHAGES
MAMMALS
MICE
ORGANS
PHAGOCYTES
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
SPLEEN
THYMUS
TOLERANCE
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BODY
CELL KILLING
CONNECTIVE TISSUE CELLS
FRACTIONATED IRRADIATION
IMMUNE REACTIONS
IRRADIATION
LYMPH NODES
LYMPHATIC SYSTEM
MACROPHAGES
MAMMALS
MICE
ORGANS
PHAGOCYTES
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
SPLEEN
THYMUS
TOLERANCE
VERTEBRATES