Colorectal carcinoma metastases: Detection with In-111-labeled monoclonal antibody CCR 086

Journal Article · Sun Jul 01 00:00:00 EDT 1990 · Radiology; (USA)

DOI:https://doi.org/10.1148/radiology.176.1.2353080· OSTI ID:6707323

Abdel-Nabi, H H; Levine, G; Lamki, L M; Murray, J L; Tauxe, W N; Shah, A N; Patt, Y Z; Doerr, R J; Klein, H A; Gona, J ^[1]

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1. Veterans Administration Medical Center, Buffalo, NY (USA)

A phase I/II clinical trial with indium-111-labeled antimucin murine monoclonal antibody (MoAb) CCR 086 was conducted. Seventeen patients with histologically proved colorectal carcinoma and known metastatic disease underwent external scintigraphy after administration of 5.5 mCi (203.5 MBq) of In-111 CCR 086 at doses of 5 and 20 mg. Of 25 known lesions, 17 were detected (sensitivity, 68%). The smallest detected lesion in the lung was 1 cm and in the liver was 1.5 cm. The serum half-life of In-111-labeled CCR 086 MoAb was approximately 64 hours. The formation of human antimouse antibody (HAMA) was detected in the serum of four of five patients who received 20 mg of MoAb. No HAMAs were detected in four patients receiving 5 mg of MoAb. No side effects were encountered. Because of effective detection of liver and lung metastases with lower doses (5-20 mg) of CCR 086 conjugated with In-111, further investigations are warranted to assess clinical and therapeutic potentials of CCR 086 in the management of colorectal cancer.

• OSTI ID: 6707323
• Journal Information: Radiology; (USA), Journal Name: Radiology; (USA) Vol. 176:1; ISSN 0033-8419; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
ANTIBODY FORMATION
BETA DECAY RADIOISOTOPES
BIOLOGICAL HALF-LIFE
BODY
CARCINOMAS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GASTROINTESTINAL TRACT
GLANDS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LARGE INTESTINE
LIVER
LUNGS
MAMMALS
MAN
METASTASES
MICE
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SCINTISCANNING
VERTEBRATES