The heritage of radiotracers for PET

Conference · Sun May 01 04:00:00 EDT 1988

OSTI ID:6706433

Fowler, J S; Wolf, A P

The history of PET research clearly demonstrates that it is advances in chemistry coupled with a detailed examination of the biochemistry of new radiotracers which has allowed the PET method to be applied to new areas of biology and medicine. Radiotracers whose regional distribution reflects glucose metabolism, neutrotransmitter activity and enzyme activity have all required the development of rapid synthetic methods for the radiotracers themselves and the characterization of their biochemical behavior. This article traces some of the advances in the production of labeled precursors and in radiotracer synthesis and evaluation which have shaped the rapidly expanding application of PET to problems in the neurosciences, in cardiology and in oncology. 54 refs.

• Research Organization: Brookhaven National Lab., (BNL) Upton, NY (USA)
• Sponsoring Organization: U.S. Department of Energy (USDOE)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6706433
• Report Number(s): BNL-41807; CONF-8805211-2; ON: DE89001608
• Country of Publication: United States
• Language: English

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440300* -- Miscellaneous Instruments-- (-1989)
47 OTHER INSTRUMENTATION
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
EMISSION COMPUTED TOMOGRAPHY
EVALUATION
HISTORICAL ASPECTS
IMAGE PROCESSING
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
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POSITRON COMPUTED TOMOGRAPHY
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TECHNOLOGY ASSESSMENT
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TRACER TECHNIQUES
USES