The heritage of radiotracers for PET
The history of PET research clearly demonstrates that it is advances in chemistry coupled with a detailed examination of the biochemistry of new radiotracers which has allowed the PET method to be applied to new areas of biology and medicine. Radiotracers whose regional distribution reflects glucose metabolism, neutrotransmitter activity and enzyme activity have all required the development of rapid synthetic methods for the radiotracers themselves and the characterization of their biochemical behavior. This article traces some of the advances in the production of labeled precursors and in radiotracer synthesis and evaluation which have shaped the rapidly expanding application of PET to problems in the neurosciences, in cardiology and in oncology. 54 refs.
- Research Organization:
- Brookhaven National Lab., (BNL) Upton, NY (USA)
- Sponsoring Organization:
- U.S. Department of Energy (USDOE)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 6706433
- Report Number(s):
- BNL-41807; CONF-8805211-2; ON: DE89001608
- Resource Relation:
- Conference: 12. Sigrid Juselius Foundation symposium on tracers in diagnostic imaging, Helsinki, Finland, 22 May 1988; Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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