Toxicity studies on agents Gb and Gd (Phase 2): Delayed neuropathy study of soman in SPF white leghorn chickens. Final technical report, July 1985-August 1991

Technical Report · Fri May 01 00:00:00 EDT 1992

OSTI ID:6702902

Bucci, T J; Parker, R M; Gosnell, P A

A dose rangefinding study, a delayed neuropathy study, and a neurotoxic esterase study, were performed in White Leghorn chickens using the organophosphate ester Soman. The hens used for the Rangefinding study were dosed once orally with 500, 250, 100, 50, 25, or 0 microns g/Kg GD, on Day 1. They were pretreated and protected daily through Day 7 with atropine. Surviving hens were euthanized with sodium pentobarbital on Day 21. The maximum tolerated dose (MTD) to be used in the Delayed Neuropathy Study was chosen based upon the rangefinding data. Fifty hens were assigned to a Single Dose Delayed Neuropathy study. Groups of ten hens were given 14.2 (MTD), 7.1 (MTD/2), 3.5 (MTD/4), 0 (negative control) microns/Kg GD or 51 0 mg/Kg tri-ortho-cresyl phosphate (TOCP) (positive control). Rangefinding study. They were evaluated for signs of neurologic toxicity/ataxia. Necropsy examination was performed on all animals. Sections of cerebellum, medulla, spinal cord (cervical, thoracic, and lumbar), both sciatic nerves and their tibial branch were examined microscopically.... Delayed neuropathy; Agents; Soman; Chickens.

• Research Organization: National Center for Toxicological Research, Jefferson, AR (United States)
• OSTI ID: 6702902
• Report Number(s): AD-A-258643/6/XAB; NCTR-TR-484
• Country of Publication: United States
• Language: English

Related Subjects

45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEFENSE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHEMICAL WARFARE AGENTS
TOXICITY
ANIMALS
ATROPINE
CEREBELLUM
CHICKENS
CONTROL
DETECTION
DOSE-RESPONSE RELATIONSHIPS
ESTERASES
ESTERS
NEMBUTAL
NERVES
PHOSPHATES
SODIUM
SPINAL CORD
ALKALI METALS
ALKALOIDS
ANESTHETICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
BARBITURATES
BIRDS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
ELEMENTS
ENZYMES
FOWL
HETEROCYCLIC COMPOUNDS
HYDROLASES
HYPNOTICS AND SEDATIVES
METALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PARASYMPATHOLYTICS
PHOSPHORUS COMPOUNDS
PROTEINS
PYRIMIDINES
VERTEBRATES
WEAPONS
450100* - Military Technology
Weaponry
& National Defense- Chemical Explosions & Explosives
560300 - Chemicals Metabolism & Toxicology