Evaluation of misonidazole peripheral neurotoxicity in rats by analysis of nerve trains evoked response

Journal Article · Fri Jan 01 04:00:00 EST 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90387-X· OSTI ID:6702336

Edwards, M S ^[1]; Bolger, C A; Levin, V A; Phillips, T L; Jewett, D L

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1. Veterans Administration Medical Center, San Francisco, CA

The clinical use of misonidazole and other nitroimidazole radiosensitizing agents is limited by the peripheral and central neurotoxicity that is produced in animals and humans. In a blinded study, rats treated with misonidazole at either 100 mg/kg or 300 mg/kg, 5 days/week for 3 weeks, were evaluated for peripheral neurotoxicity using nerve trains evoked responses. Only one rat treated at a dose of 100 mg/kg developed symptoms and signs of neurotoxicity, while all rats treated at 300 mg/kg developed these signs and symptoms. Nerve trains analysis made possible a diagnosis of neurotoxicity before overt clinical signs appeared. This test is non-invasive and may be useful for evaluating patients receiving nitroimidazole radiosensitizers as part of a radiation therapy regimen.

• OSTI ID: 6702336
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:1; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152 -- Radiation Effects on Animals-- Animals
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BIOASSAY
BIOLOGICAL EFFECTS
DRUGS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
MAMMALS
MEDICINE
MISONIDAZOLE
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOLOGICAL CHANGES
RADIOLOGY
RADIOSENSITIZERS
RADIOTHERAPY
RATS
RODENTS
THERAPY
TOXICITY
VERTEBRATES