Method for differential diagnosis of T cell leukemias using monoclonal antibodies
Patent
·
OSTI ID:6700381
This patent describes monoclonal antibody 3-3 (HB8369) and 3-40 (HB8368) not capable of immunological reaction with normal, human peripheral T or B blood cell antigens, normal human thymocyte antigens or normal, human bone marrow precursor cell antigens but capable of immunological reaction with separate and distinct T-ALL leukemia antigens (T-ALL) having molecular weights of approximately 35-40,000 KD. The monoclonal antibodies are capable of distinguishing T-ALL leukemia from cutaneous T-cell lymphoma (CTCL), adult T cell leukemia (ATL) and T-cell chronic lymphocytic leukemia (T-CLL) and are further capable of subsetting T-ALL leukemia into E-Rosette positive and E-Rosette negative cells.
- Assignee:
- Memorial Sloan-Kettering Institute Cancer Center, New York, NY
- Patent Number(s):
- US 4645738
- OSTI ID:
- 6700381
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANTIBODIES
ANTIGENS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
DIAGNOSIS
DIAGNOSTIC USES
DISEASES
HEMIC DISEASES
HUMAN POPULATIONS
IMMUNOLOGY
LEUKEMIA
LYMPHOMAS
MATERIALS
MOLECULAR WEIGHT
MONOCLONAL ANTIBODIES
NEOPLASMS
POPULATIONS
SOMATIC CELLS
THYMOCYTES
USES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANTIBODIES
ANTIGENS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
DIAGNOSIS
DIAGNOSTIC USES
DISEASES
HEMIC DISEASES
HUMAN POPULATIONS
IMMUNOLOGY
LEUKEMIA
LYMPHOMAS
MATERIALS
MOLECULAR WEIGHT
MONOCLONAL ANTIBODIES
NEOPLASMS
POPULATIONS
SOMATIC CELLS
THYMOCYTES
USES