The effect of diet on tumor necrosis factor stimulation of hepatic lipogenesis

Journal Article · Fri Jun 01 04:00:00 EDT 1990 · Metabolism, Clinical and Experimental; (USA)

DOI:https://doi.org/10.1016/0026-0495(90)90030-G· OSTI ID:6699211

Feingold, K R; Soued, M; Serio, M K; Adi, S; Moser, A H; Grunfeld, C ^[1]

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1. Univ. of California, San Francisco (USA)

In this study, we determined the effects of tumor necrosis factor (TNF) on serum lipid levels and hepatic lipid synthesis in animals whose diets and feeding conditions were varied to induce changes in baseline serum lipid levels and/or rates of hepatic lipid synthesis. In animals studied at both the nadir and peak of the diurnal cycle of hepatic lipid synthesis, TNF acutely increases serum triglyceride levels, stimulates hepatic fatty acid synthesis, and increases the quantity of newly synthesized fatty acids found in the serum. Similarly, in animals ingesting either high-sucrose or cholesterol-enriched diets, TNF induces the characteristic rapid increase in serum triglyceride levels, hepatic fatty acid synthesis, and quantity of labeled fatty acids in the serum. In animals fed a diet high in triglycerides, using either corn oil or lard, TNF stimulates hepatic fatty acid synthesis and increases the quantity of newly synthesized fatty acids in the serum, but serum triglyceride levels do not change. However, TNF inhibits gastric emptying, which results in a marked decrease in fat absorption in TNF-treated animals. It is likely that a decrease in the dietary contribution to serum triglyceride levels during high-triglyceride feeding counterbalances the increased hepatic contribution induced by TNF treatment. In animals fasted before TNF administration there was no acute change in either serum lipid levels, hepatic fatty acid synthesis, or the quantity of labeled fatty acids in the serum. Thus, TNF stimulates hepatic fatty acid synthesis and increases serum triglyceride levels under many diverse dietary conditions, suggesting that there is a strong linkage between the immune system and lipid metabolism that is independent of most dietary manipulations and may be of fundamental importance in the body's response to infection.

• OSTI ID: 6699211
• Journal Information: Metabolism, Clinical and Experimental; (USA), Journal Name: Metabolism, Clinical and Experimental; (USA) Vol. 39:6; ISSN METAA; ISSN 0026-0495
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CHOLESTEROL
DEUTERIUM
DIET
DIGESTIVE SYSTEM
DISACCHARIDES
ESTERS
FASTING
GASTROINTESTINAL TRACT
GLANDS
GROWTH FACTORS
HYDROGEN COMPOUNDS
HYDROGEN ISOTOPES
HYDROXY COMPOUNDS
INTESTINES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGHT NUCLEI
LIPIDS
LIVER
MAMMALS
MITOGENS
NUCLEI
ODD-ODD NUCLEI
OLIGOSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PROTEINS
RATS
REACTION KINETICS
RODENTS
SACCHARIDES
SACCHAROSE
SMALL INTESTINE
STABLE ISOTOPES
STEROIDS
STEROLS
SYNTHESIS
TRACER TECHNIQUES
TRIGLYCERIDES
TUMOR CELLS
VERTEBRATES
WATER