Comparative metabolism and fate of fenvalerate in Japanese quail (Coturnix coturnix japonica) and rats (Rattus norwegicus)

Journal Article · · J. Agric. Food Chem.; (United States)

DOI:https://doi.org/10.1021/jf00072a001· OSTI ID:6698613

Mumtaz, M M; Menzer, R E

Adult Japanese quail were administered 100 mg/kg chlorophenyl-labeled (/sup 14/C)fenvalerate, ..cap alpha..-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)isovalerate, for study of its distribution, elimination, and metabolism. Ninety percent of the administered dose was eliminated in the excreta within the first 24 h. In addition to fenvalerate, the following metabolites were present: benzeneacetic acid, 4-chloro-..cap alpha..-(1-methylethyl)-,cyano(3-phenoxy-4-hydroxyphenyl)methyl ester (4'-OH-fenvalerate); benzeneacetic acid, 4-chloro-..cap alpha..-(1-methylethyl)-,(aminocarbonyl)(3-phenoxyphenyl)methyl ester (CONH/sub 2/-fenvalerate); 4-chloro-..cap alpha..-(1-methylethyl)benzeneacetic acid(Cl-V acid); 4-chloro-..cap alpha..-(2-hydroxy-1-methylethyl)benzeneacetic acid(4-OH-Cl-V acid). In time course studies radiocarbon peaked at 3 h (9..mu..g/g) in the liver and gradually declined, while in the blood it peaked within 2 h and fell quickly to an equilibrium value of 1.5 ..mu..g/mL blood. In liver microsomal and isolated heptatocyte preparations of Japanese quail and rat, the following metabolites were identified: Cl-V acid, 4-OH-Cl-V acid, 4'-OH-fenvalerate, CONH/sub 2/-fenvalerate. Oxidation was found to be the predominant route of degradation either pre- or post-hydrolysis of the parent compound. Rapid excretion, lesser absorption, and faster metabolism probably explain the lower toxicity of fenvalerate to birds compared to rats.

• Research Organization: Univ. of Maryland, College Park
• OSTI ID: 6698613
• Journal Information: J. Agric. Food Chem.; (United States), Journal Name: J. Agric. Food Chem.; (United States) Vol. 34:6; ISSN JAFCA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MATERIALS
BIRDS
BLOOD
BODY
BODY FLUIDS
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CLEARANCE
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
DISTRIBUTION
EXCRETION
GLANDS
ISOTOPE APPLICATIONS
ISOVALERIC ACID
LABELLED COMPOUNDS
LIVER
MAMMALS
MATERIALS
METABOLISM
METABOLITES
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PESTICIDES
RATS
RODENTS
TISSUE DISTRIBUTION
TOXICITY
TRACER TECHNIQUES
VERTEBRATES