Regional assignment of the human homebox-containing gene EN1 to chromosome 2q13-q21

Journal Article · Fri Jan 01 04:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1045· OSTI ID:6697205

Koehler, A; Muenke, M ^[1]; Logan, C ^[2]; Joyner, A L ^[3]

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1. Univ. of Pennsylvania, Philadelphia (United States)
2. Univ. of Toronto (Canada)
3. Univ. of Toronto (Canada) Samuel Lunenfeld Research Institute, Toronto (Canada)

The human homeobox-containing genes EN1 and EN2 are closely related to the Drosophila pattern formation gene engrailed (en), which may be important in brain development, as shown by gene expression studies during mouse embryogenesis. Here, we have refined the localization of EN1 to human chromosome 2q13-q21 using a mapping panel of rodent/human cell hybrids containing different regions of chromosome 2 and a lymphoblastoid cell line with an interstitial deletion, del(2) (q21-q23.2). This regional assignment of EN1 increases to 22 the number of currently known genes on human chromosome 2q that have homologs on the proximal region of mouse chromosome 1. 15 refs., 2 figs.

• OSTI ID: 6697205
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 15:1; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL GROWTH
ANIMALS
ARTHROPODS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHROMOSOMES
CONTROL
DIPTERA
DROSOPHILA
FLIES
FRUIT FLIES
GENES
GENETIC MAPPING
GROWTH
HUMAN CHROMOSOME 2
HUMAN CHROMOSOMES
INSECTS
INVERTEBRATES
MAPPING
NERVOUS SYSTEM
ORGANS