Xenon-133 determination of muscle blood flow: Use in evaluating cardioactive drugs
Cardioactive drugs may effect both the central and peripheral circulatory systems. The effects on the central and peripheral circulatory systems of chronic Captorpril therapy in 7 pts with severe congestive heart failure (CHF) were evaluated simultaneously. Skeletal muscle blood flow (SMBF) determined using 133-Xe washout and a Cd/Te detector, oxygen consumption (VO/sub 2/), and radial artery and femoral vein O/sub 2/ concentration difference (A-V) were determined at rest and peak upright bicycle exercise before (BT) and after (AT) 6-12 weeks of Captopril therapy. In CI pts there was a significant increase in VO/sub 2/ and SMBF AT vs BT. In contrast, in CNC pts there was no change in VO/sub 2/ and a significant decrease in SMBF AT vs BT. In pts with severe CHF who are CI, there is an apparent fall in peripheral vascular resistance (PVR). In contrast, in CNC pts there is an increase in PVR. This study demonstrates that SMBF determines using 133-Xe is an important method for determining the effects of cardioactive drugs.
- Research Organization:
- Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY
- OSTI ID:
- 6696889
- Report Number(s):
- CONF-850611-; TRN: 87-015287
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARDIOVASCULAR AGENTS
MONITORING
PERFORMANCE
THERAPEUTIC USES
CARDIOVASCULAR DISEASES
THERAPY
HEART
BLOOD FLOW
EXERCISE
XENON 133
ARTERIES
BLOOD CIRCULATION
CADMIUM
CLEARANCE
FAILURES
MUSCLES
OXYGEN
SKELETON
TELLURIUM
VOLUME
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELEMENTS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
METALS
NONMETALS
NUCLEI
ORGANS
RADIOISOTOPES
SEMIMETALS
USES
XENON ISOTOPES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)