Fatal hemorrhagic cystitis induced by pelvic irradiation and cyclophosphamide therapy. Case reports and review
Journal Article
·
· Minnesota Medicine; (USA)
OSTI ID:6694367
The potent cytotoxic drug cyclophosphamide has been used extensively for neoplastic and non-neoplastic diseases. Patients taking this drug may have received or may be receiving pelvic irradiation concurrently. This report describes two patients who developed fatal hemorrhagic cystitis induced by pelvic irradiation and cyclophosphamide therapy. Etiology, incidence, pathologic descriptions, and diagnostic and therapeutic aspects of this entity are described. The incidence and risk of serious, life-threatening bladder hemorrhage from cyclophosphamide therapy is increased by prior or concurrent pelvic irradiation. Alternative cytotoxic, non-urotoxic chemotherapy should be used in these high-risk patients.
- OSTI ID:
- 6694367
- Journal Information:
- Minnesota Medicine; (USA), Vol. 73:5; ISSN 0026-556X
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTINEOPLASTIC DRUGS
TOXICITY
COMBINED THERAPY
SIDE EFFECTS
NEOPLASMS
OVARIES
UROGENITAL SYSTEM DISEASES
RADIOINDUCTION
BIOLOGICAL RADIATION EFFECTS
BLADDER
HEMORRHAGE
RADIATION INJURIES
BIOLOGICAL EFFECTS
BODY
DISEASES
DRUGS
FEMALE GENITALS
GONADS
INJURIES
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
SYMPTOMS
THERAPY
URINARY TRACT
560151* - Radiation Effects on Animals- Man
550602 - Medicine- External Radiation in Diagnostics- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTINEOPLASTIC DRUGS
TOXICITY
COMBINED THERAPY
SIDE EFFECTS
NEOPLASMS
OVARIES
UROGENITAL SYSTEM DISEASES
RADIOINDUCTION
BIOLOGICAL RADIATION EFFECTS
BLADDER
HEMORRHAGE
RADIATION INJURIES
BIOLOGICAL EFFECTS
BODY
DISEASES
DRUGS
FEMALE GENITALS
GONADS
INJURIES
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
SYMPTOMS
THERAPY
URINARY TRACT
560151* - Radiation Effects on Animals- Man
550602 - Medicine- External Radiation in Diagnostics- (1980-)