Serum parathyroid hormone (PTH) in pregnant women determined by an immunoradiometric assay for intact PTH

Journal Article · Sat Oct 01 04:00:00 EDT 1988 · J. Clin. Endocrinol. Metab.; (United States)

DOI:https://doi.org/10.1210/jcem-67-4-850· OSTI ID:6691211

Davis, O K; Hawkins, D S; Rubin, L P; Posillico, J T; Brown, E M; Schiff, I

Most studies of circulating PTH levels using traditional RIAs have supported the concept of physiological hyperparathyroidism of pregnancy, with pregnant women having serum immunoreactive PTH levels significantly higher than those in nonpregnant subjects. However, such RIAs are insensitive and often detect inactive PTH fragments, so that the correlation between PTH immunoreactivity and bioactivity is poor. Employing a new intact PTH immunoradiometric assay (Allegro-Nichols), we reassessed the effects of pregnancy on parathyroid function. The mean serum PTH level in 81 pregnant women was 14.4 +/- 6.3 (+/- SD) compared to 24.8 +/- 9.0 ng/L in 11 normally cycling nonpregnant women (P less than 0.001). The mean serum total and ionized calcium levels in the 2 groups were similar. In 5 of the pregnant women, serum bioactive PTH, determined by cytochemical bioassay, was slightly lower (7.7 +/- 3.4 ng/L) than in normal individuals (11.1 +/- 1.9 ng/L). Our findings suggest, in contrast with the results of most previous studies, that serum intact PTH may decline during pregnancy.

• Research Organization: Brigham and Women's Hospital, Boston, MA (USA)
• OSTI ID: 6691211
• Journal Information: J. Clin. Endocrinol. Metab.; (United States), Journal Name: J. Clin. Endocrinol. Metab.; (United States) Vol. 67:4; ISSN JCEMA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
DIAGNOSIS
DISEASES
DYNAMIC FUNCTION STUDIES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
HYPERPARATHYROIDISM
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
ORGANS
PARATHORMONE
PARATHYROID GLANDS
PEPTIDE HORMONES
PREGNANCY
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
TRACER TECHNIQUES