Tomographic assessment of cerebral perfusion using a single-photon emitter (Krypton-81m) and a rotating gamma camera

Journal Article · Mon Dec 01 04:00:00 EST 1980 · J. Nucl. Med.; (United States)

OSTI ID:6689039

Fazio, F; Fieschi, C; Collice, M; Nardini, M; Banfi, F; Possa, M; Spinelli, F

Continuous carotid infusion of short-lived krypton-81m (t/sub 1/2 13 sec) yields an assessment of regional cerebral perfusion. This assessment can be obtained in three dimensions if activity is recorded with a rotating gamma camera and a computer to reconstruct krypton-81m distribution in tomographic sections. These showed several advantages over conventional views: (a) visualization of blood-flow distribution within brain structures (gray and white matter, basal ganglia); (b) more accurate location and evaluation of areas of relatively reduced or increased perfusion; (c) better definition of patterns of collateral circulation; (d) greater sensitivity and specificity in detecting and defining blood-flow changes during physiological activation studies. A limitation of the krypton-81m technique is its invasiveness. However, this study shows that the combination of new advances in radiochemistry with single-photon emission computed tomography may result in accessible methods for assessing, noninvasively and in three dimensions, the behavior of cerebral function in man.

• Research Organization: Hammersmith Hospital, London, England
• OSTI ID: 6689039
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:12; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CAMERAS
CENTRAL NERVOUS SYSTEM
CEREBRUM
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GAMMA CAMERAS
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KRYPTON 81
KRYPTON ISOTOPES
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEI
ORGANS
PATIENTS
PERFUSED TISSUES
PHOTON COMPUTED TOMOGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
TISSUES
TOMOGRAPHY
USES
YEARS LIVING RADIOISOTOPES