Bioassay of polycyclic aromatic hydrocarbons
A positive relationship was found between the photodynamic activity of 24 polycyclic aromatic hydrocarbons versus published results on the mutagenicity, carcinogenicity, and initiation of unscheduled DNA synthesis. Metabolic activation of benzo(a)pyrene resulted in detection of increased mutagenesis in Paramecium tetraurelia as found also in the Ames Salmonella assay. The utility of P. tetraurelia as a biological detector of hazardous polycyclic aromatic hydrocarbons is discussed.
- Research Organization:
- Wyoming Univ., Laramie (USA)
- DOE Contract Number:
- AS02-77EV04477
- OSTI ID:
- 6680649
- Report Number(s):
- DOE/EV/04477-T2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
560304 -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BACTERIA
BENZOPYRENE
CARCINOGENESIS
CHEMISTRY
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
CORRELATIONS
HYDROCARBONS
INVERTEBRATES
METABOLIC ACTIVATION
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENESIS
ORGANIC COMPOUNDS
PARAMECIUM
PATHOGENESIS
PHOTOCHEMISTRY
POLYCYCLIC AROMATIC HYDROCARBONS
PROTOZOA
SALMONELLA
SCREENING
560304 -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BACTERIA
BENZOPYRENE
CARCINOGENESIS
CHEMISTRY
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
CORRELATIONS
HYDROCARBONS
INVERTEBRATES
METABOLIC ACTIVATION
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENESIS
ORGANIC COMPOUNDS
PARAMECIUM
PATHOGENESIS
PHOTOCHEMISTRY
POLYCYCLIC AROMATIC HYDROCARBONS
PROTOZOA
SALMONELLA
SCREENING