Comparison of mercury levels in maternal blood, fetal cord blood, and placental tissues
Journal Article
·
· Am. J. Obstet. Gynecol.; (United States)
OSTI ID:6680338
Previous studies have reported that mercury accumulates in cord blood during pregnancy. This study was carried out to determine where in cord blood the mercury accumulates, i.e., in cord erythrocytes, in cord plasma, or in both, and to determine whether the predominant form of mercury which accumulates is methyl or inorganic mercury. From our data it is clear that methyl mercury accumulates in cord erythrocytes: A total of 30% more methyl mercury was found in fetal erythrocytes than in maternal erythrocytes. Also correlation analysis of the methyl mercury levels in maternal and fetal erythrocytes showed a strong correlation (r = 0.87). In regard to inorganic mercury, the highest concentration was found in the placenta, suggesting a barrier role, but a significant correlation (r = 0.62) was also found between the maternal and fetal plasma levels of inorganic mercury. Moreover, the inorganic mercury concentration per gram of plasma was higher in fetal cord plasma than in maternal plasma. Overall, the relative levels of methyl and inorganic mercury reported here varied considerably in maternal and fetal erythrocytes, plasma, and in the placenta, but all of the levels were low (< 6 ng Hg/gm of tissue) and in agreement with total mercury levels reported by others.
- Research Organization:
- Perinatal Clinical Research Center, Cleveland, OH
- OSTI ID:
- 6680338
- Journal Information:
- Am. J. Obstet. Gynecol.; (United States), Journal Name: Am. J. Obstet. Gynecol.; (United States) Vol. 139:2; ISSN AJOGA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550500 -- Metabolism
551000 -- Physiological Systems
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL ANALYSIS
COMPARATIVE EVALUATIONS
CORRELATIONS
DATA ANALYSIS
ELEMENTS
ERYTHROCYTES
FETAL MEMBRANES
FETUSES
MATERIALS
MEMBRANES
MERCURY
METABOLISM
METALS
METHYLMERCURY
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
PATIENTS
PHYSIOLOGY
PLACENTA
PLASMA
PREGNANCY
QUANTITY RATIO
SENSITIVITY
551000 -- Physiological Systems
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL ANALYSIS
COMPARATIVE EVALUATIONS
CORRELATIONS
DATA ANALYSIS
ELEMENTS
ERYTHROCYTES
FETAL MEMBRANES
FETUSES
MATERIALS
MEMBRANES
MERCURY
METABOLISM
METALS
METHYLMERCURY
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
PATIENTS
PHYSIOLOGY
PLACENTA
PLASMA
PREGNANCY
QUANTITY RATIO
SENSITIVITY