Pathologic findings in canine brain irradiated with fractionated fast neutrons or photons

Journal Article · Mon Dec 01 04:00:00 EST 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575493· OSTI ID:6673551

Zook, B C ^[1]; Bradley, E W; Casarett, G W; Rogers, C C

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1. George Washington Univ. Medical Center, Washington, DC

Thirty-seven adult male purebred beagles received total doses of 1333, 2000, 3000, or 4500 rad of fast neutrons (15 MeV av) in 4 fractions/week for 7 weeks to the entire brain. Nineteen dogs received 4000, 6000, or 9000 rad of photons (/sup 60/Co) in an identical fractionation pattern. Dogs receiving 4500, 3000, and 2000 rad of neutrons and 9000 rad of photons developed neurologic signs and died or were euthanatized when moribund followed irradiation. Cerebrospinal fluid contained excess protein and erythrocytes during and sometimes before the generally brief course. The onset of neurologic symptoms was usually followed by a moribund state in less than 48 h. The relative biological effectiveness (RBE) as measured by onset of neurologic symptoms and mortality was greater than 4.5. Gross changes included hemorrhage, edema, and malacia primarily in the white matter, especially the corona radiata, cerebellar white matter, corpus callosum, and corpus fornicis. One beagle developed a brain tumor and died 1207 days following 1333-rad neutron irradiation.

• OSTI ID: 6673551
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 84:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBROSPINAL FLUID
COBALT 60
COBALT ISOTOPES
DELAYED RADIATION EFFECTS
DISEASES
DOGS
EDEMA
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ERYTHROCYTES
EVALUATION
FAST NEUTRONS
FERMIONS
FRACTIONATED IRRADIATION
GAMMA RADIATION
HADRONS
HEMORRHAGE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NERVOUS SYSTEM
NEUTRONS
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RBE
SIDE EFFECTS
SYMPTOMS
VERTEBRATES
YEARS LIVING RADIOISOTOPES