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Intestinal uptake of bile acids: effect of external abdominal irradiation. [Rats]

Journal Article · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
; ;

Abdominal irradiation has recently been shown to influence the uptake of hexoses, amino acids, fatty acids and cholesterol into the jejunum of rats. The present studies were undertaken with a previously validated in vitro technique to determine the effect of abdominal irradiation from a cesium source on the rates of uptake of six bile acids into the jejunum, ileum, and colon. The results show that: 1) there likely are multiple ileal carriers for bile acids: 2) abdominal irradiation has a variable effect on these carriers; 3) the passive permeability to bile acids varies with the bile acid and with the site along the intestine; and 4) abdominal irradiation is associated with a rise in the colonic permeability to only some bile acids.

Research Organization:
Univ. of Alberta, Edmonton
OSTI ID:
6667280
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:5; ISSN IOBPD
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABDOMEN
ABSORPTION
ALKALI METAL ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILE ACIDS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARBOXYLIC ACIDS
CESIUM 137
CESIUM ISOTOPES
DATA
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
GAMMA RADIATION
HYDROXY COMPOUNDS
INFORMATION
INTESTINAL ABSORPTION
IONIZING RADIATIONS
ISOTOPES
KINETICS
MAMMALS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PERMEABILITY
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RATS
REACTION KINETICS
RODENTS
STEROIDS
STEROLS
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES