Organochlorine compounds in human breast fat from deceased with and without breast cancer and in a biopsy material from newly diagnosed patients undergoing breast surgery

Journal Article · Fri Jun 01 04:00:00 EDT 1984 · Environ. Res.; (United States)

OSTI ID:6665552

Unger, M; Kiaer, H; Blichert-Toft, M; Olsen, J; Clausen, J

Epidemiological studies have related the incidence of mammary cancer to the dietary intake of fat and/or meat. Since organochlorine compounds (e.g., polychlorinated biphenyls (PCB) and DDT (and its metabolite DDE)) are accumulated in the adipose tissue it was tempting to suggest a relationship between levels of PCB and DDT (i.e., DDT + DDE) in breast fat tissue and the occurrence of mammary cancer. To elucidate this theory, the organochlorine levels of 14 breast fat tissue samples from breast cancer patients and similar samples from 18 decreased mammary cancer patient were compared to that of 21 similar samples from noncancer patients and finally to adipose tissue samples from 35 non-cancer autopsy specimens. No significant differences were traced. Thus it seems that the accumulation of PCB and DDT measured in breast fat tissue do not relate to the occurrence of mammary cancer.

• Research Organization: Roskilde Univ., Denmark
• OSTI ID: 6665552
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 34:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADIPOSE TISSUE
ANIMAL TISSUES
AROMATICS
BIOLOGICAL ACCUMULATION
BODY
CHLORINATED AROMATIC HYDROCARBONS
CONNECTIVE TISSUE
DIET
DISEASES
EPIDEMIOLOGY
ETIOLOGY
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
MAMMARY GLANDS
NEOPLASMS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
TISSUES