Modification of pH induced cellular inactivation by irradiation-glial cells

Conference · Sat Dec 01 04:00:00 EST 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:6665017

Roettinger, E M ^[1]; Mendonca, M

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1. Univ. of Cologne, Germany

Human cells of glial origin were examined for clonogenic survival after exposure to subnormal pH of the extracellular fluid for 0 to 5 days at 37/sup 0/C. The surviving fraction decreased at pH values between 6.7 and 6.4 to 10% within 2 days. Cells that survived irradiation demonstrated a decreased sensitivity to an acid extracellular fluid. The radiation response function was established with and without incubation at pH 6.7 for 66 hours. Doses above 4 Gray resulted in a higher survival at pH 6.7 than at pH 7.4, if pH was reduced 15 hours prior to irradiation. Enhanced clonogenic survival after irradiation under conditions of continuous acidity in the extracellular space may be a further explanation for poor local control of malignant tumors in clinical radiation therapy.

• OSTI ID: 6665017
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 6:12
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
DISEASES
EARLY RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
ENERGY RANGE
IONIZING RADIATIONS
MEV RANGE
MEV RANGE 01-10
NEOPLASMS
NERVOUS SYSTEM DISEASES
PH VALUE
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
SURVIVAL CURVES
SYNERGISM
TUMOR CELLS
X RADIATION