Chemical mutagenesis testing in Drosophila. I. Comparison of positive and negative control data for sex-linked recessive lethal mutations and reciprocal translocations in three laboratories

Journal Article · Sun Jan 01 04:00:00 EST 1984 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860060207· OSTI ID:6656805

Woodruff, R C; Mason, J M; Valencia, R; Zimmering, S

As part of the validation phase of the Drosophila melanogaster segment of the National Toxicology Program, a comparison has been made of positive and negative controls for sex-linked recessive lethal mutations and reciprocal translocations from three laboratories. This comparison involves approximately 700,000 spontaneous recessive lethal mutation tests, 70,000 spontaneous translocation tests, and screens for genetic damage induced by N-nitrosodimethylamine and ..beta..-propiolactone. Spontaneous frequencies for lethal mutations and translocations were homogeneous in the laboratories regardless of solvent or broods sampled. Inhomogeneity was observed in induced frequencies among laboratories, but the variation was no greater than that found within a laboratory.

• Research Organization: Bowling Green State Univ., OH
• OSTI ID: 6656805
• Journal Information: Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 6:2; ISSN ENMUD
• Country of Publication: United States
• Language: English

Related Subjects

560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
ARTHROPODS
DIPTERA
DROSOPHILA
ESTERS
FLIES
FRUIT FLIES
HETEROCYCLIC COMPOUNDS
INSECTS
INTERLABORATORY COMPARISONS
INVERTEBRATES
LACTONES
LETHAL MUTATIONS
MUTAGEN SCREENING
MUTATIONS
NITROSAMINES
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RESEARCH PROGRAMS
SCREENING
SEX DEPENDENCE
TESTING
TRANSLOCATION
VALIDATION