Gallium 67 citrate scanning and serum angiotensin converting enzyme levels in sarcoidosis

Journal Article · Wed Sep 01 00:00:00 EDT 1982 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.144.4.6287521· OSTI ID:6656686

Gupta, R G ^[1]; Bekerman, C; Sicilian, L; Oparil, S; Pinsky, S M; Szidon, J P

---

1. Michael Reese Hospital, Chicago, IL

Gallium 67 citrate scans and serum angiotension converting enzyme (ACE) levels were obtained in 54 patients with sarcoidosis and analyzed in relation to clinical manifestation. /sup 67/Ga scans were abnormal in 97% of patients with clinically active disease (n = 30) and in 71% of patients with inactive disease (n = 24). Serum ACE levels were abnormally high (2 standard deviations above the control mean) in 73% of patients with clinically active disease and in 54% of patients with inactive disease. Serum ACE levels correlated significantly with /sup 67/Ga uptake score (r = .436; p < .005). The frequency of abnormal /sup 67/Ga scans and elevated serum ACE levels suggests that inflammatory activity with little or no clinical expression is common in sarcoidosis. Abnormal /sup 67/Ga scans were highly sensitive (97%) but had poor specificity (29%) to clinical disease activity. The accuracy of negative prediction of clinical activity by normal scans (87%) was better than the accuracy of positive prediction of clinical activity by abnormal scans (63%). /sup 67/Ga scans can be used to support the clinical identification of inactive sarcoidosis.

• OSTI ID: 6656686
• Journal Information: Radiology; (United States), Vol. 144:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GALLIUM 67
SCINTISCANNING
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
DIAGNOSIS
CITRATES
ENZYME ACTIVITY
INFLAMMATION
PATIENTS
BETA DECAY RADIOISOTOPES
CARBOXYLIC ACID SALTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
PATHOLOGICAL CHANGES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SYMPTOMS
550601* - Medicine- Unsealed Radionuclides in Diagnostics