Role of surface complexed iron in oxidant generation and lung inflammation induced by silicates
Technical Report
·
OSTI ID:6656508
The hypothesis was tested that silica and silicate dusts complex iron on their surface and that this iron increases (1) in vitro oxidant generation, and mediator release by alveolar macrophages, and (2) acute inflammatory lung injury. Silica and silicates were found to complex more than ten times the Fe(3+) onto their surfaces than did a biologically inactive dust, titanium dioxide. In vivo generation of oxidants by alveolar macrophages measured after exposure to dusts was increased by surface complexed iron. Also, acute inflammatory lung injury after intratracheal injection of silica dusts was made more severe by surface iron. The authors conclude that silica and silicate surfaces complex Fe(3+) to increase oxidant generation and mediator release by alveolar macrophages, and to increase acute lung injury in the rat.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (United States). Health Effects Research Lab.
- OSTI ID:
- 6656508
- Report Number(s):
- PB-93-156297/XAB; EPA--600/J-93/025
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSTRACTS
ANIMAL CELLS
ANIMALS
CONNECTIVE TISSUE CELLS
DISEASES
DOCUMENT TYPES
DUSTS
ELEMENTS
HYPOTHESIS
IN VITRO
IN VIVO
INFLAMMATION
INJECTION
INTAKE
IRON
LEADING ABSTRACT
MACROPHAGES
MAMMALS
METALS
MINERALS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PHAGOCYTES
RADICALS
RATS
RODENTS
SILICATES
SILICON COMPOUNDS
SOMATIC CELLS
SYMPTOMS
TITANIUM
TOXICITY
TRANSITION ELEMENTS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSTRACTS
ANIMAL CELLS
ANIMALS
CONNECTIVE TISSUE CELLS
DISEASES
DOCUMENT TYPES
DUSTS
ELEMENTS
HYPOTHESIS
IN VITRO
IN VIVO
INFLAMMATION
INJECTION
INTAKE
IRON
LEADING ABSTRACT
MACROPHAGES
MAMMALS
METALS
MINERALS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PHAGOCYTES
RADICALS
RATS
RODENTS
SILICATES
SILICON COMPOUNDS
SOMATIC CELLS
SYMPTOMS
TITANIUM
TOXICITY
TRANSITION ELEMENTS
VERTEBRATES