Zygote-derived developmental anomalies, a new endpoint of mutagenesis in mice

Conference · Fri Jan 01 00:00:00 EST 1988

OSTI ID:6656297

Generoso, W M; Rutledge, J C

There are many chemicals to which certain groups of humans are exposed and for which induction of transmissible mutations in mice has been demonstrated. Assessment of genetic risk to humans from these environmental mutagens requires accurate identification and quantification in experimental systems of the types of mutagenic damage that they can produce in the germ line and which can be transmitted to the conceptuses. Conventionally the types of genetic damage considered in this process are gene mutations (dominant, semidominant, and recessive), small deficiencies, structural chromosomal anomalies (reciprocal translocations, inversions, duplications, etc.), and numerical chromosomal anomalies (whole chromosomes missing or in excess). This report presents yet another type of mutagenic response, albeit its nature is still unknown. 13 refs.

• Research Organization: Oak Ridge National Lab., TN (USA); Children's Hospital and Medical Center, Seattle, WA (USA). Dept. of Labs.
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 6656297
• Report Number(s): CONF-881070-2; ON: DE89003929
• Resource Relation: Conference: Symposium on multi-level health effects research: molecules to man, Richland, WA, USA, 17 Oct 1988; Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DOMINANT MUTATIONS
MUTATION FREQUENCY
HUMAN POPULATIONS
RISK ASSESSMENT
CHROMOSOMAL ABERRATIONS
GERM CELLS
LETHAL MUTATIONS
MICE
MUTAGENS
PRENATAL EXPOSURE
SEX DEPENDENCE
ANIMALS
MAMMALS
MUTATIONS
POPULATIONS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology