Age response of EUE cells exposed to 31-MeV protons

Journal Article · Wed Sep 01 04:00:00 EDT 1982 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575885· OSTI ID:6654699

Bettega, D ^[1]; Fuhrman Conti, A M; Gariboldi, L; Pelucchi, M T; Scaioli, E; Tallone Lombardi, L

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1. Univ. of Milan, Italy

Cells synchronized by mitotic selection were irradiated at various times during the first generation cycle with 1.75 and 3.5 Gy of 31-MeV protons and then analyzed both for lethality and for chromosome aberrations. The results showed a maximum of radiosensitivity in late G/sub 1/-early S followed by an increase in resistance to a maximum in S in both endpoints of damage. For both types of effect, early to mid G/sub 1/ is definitely less sensitive than mid to late G/sub 1/. The ratios between the maximum and minimum sensitivity were approximately 1.4 and 2 for 1.75 and 3.5 Gy, respectively. These values agree with data reported to the literature on different mammalian cell lines exposed to X rays at comparable survival levels. For both dose values, the logarithm of the surviving reaction at various times of the generation cycle is linearly related to the corresponding chromosomal aberration frequency, with 37% survival corresponding to about one aberration per cell.

• OSTI ID: 6654699
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 91:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CYCLE
CELL KILLING
CHROMOSOMAL ABERRATIONS
DOSE-RESPONSE RELATIONSHIPS
ELEMENTARY PARTICLES
ENERGY RANGE
FERMIONS
HADRONS
MEV RANGE
MEV RANGE 10-100
MUTATIONS
NUCLEONS
PROTONS
RADIATION EFFECTS
RADIOINDUCTION
SURVIVAL CURVES