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Effects of whole-body irradiation on neonatally thymectomized mice. Incidence of benign and malignant tumors

Journal Article · · Am. J. Pathol.; (United States)
OSTI ID:6653635
; ;
The individual and combined effects of neonatal thymectomy and whole-body irradiation on the prevalence of benign and malignant tumors in germ-free female mice of the Charles Rivers line were studied to determine if a portion of the tumorigenic effects of irradiation can be attributed to injury of the thymic-dependent component of the immune response. Neonatal thymectomy increased (a) the incidence of benign and malignant tumors and (b) the prevalence of multiple primary neoplasms in an individual mouse. Whole-body exposure to 700 rad at 6 weeks of age further increased the incidence of tumors, but the relative magnitude of this increase was less pronounced than in sham-operated controls. Thus, the cumulative effects of thymectomy plus irradiation are less pronounced than the sum of the individual effects. One of several possible explanations for this observation is that a portion of the carcinogenic effects of whole-body irradiation is mediated by suppression of the thymic-dependent component of the immune response.
Research Organization:
Univ. of New Mexico, Albuquerque
OSTI ID:
6653635
Journal Information:
Am. J. Pathol.; (United States), Journal Name: Am. J. Pathol.; (United States) Vol. 91:2; ISSN AJPAA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ETIOLOGY
EXTERNAL IRRADIATION
IMMUNOSUPPRESSION
INJURIES
IRRADIATION
MAMMALS
MEDICINE
MICE
NEONATES
NEOPLASMS
PATHOGENESIS
PRENATAL IRRADIATION
RADIATION EFFECTS
RADIATION INJURIES
RESPONSE MODIFYING FACTORS
RODENTS
SURGERY
THYMECTOMY
VERTEBRATES
WHOLE-BODY IRRADIATION