Laue diffraction protein crystallography at the National Synchrotron Light Source
- Scripps Institution of Oceanography, La Jolla, CA (United States)
- Brookhaven National Lab., Upton, NY (United States)
- Chicago Univ., IL (United States)
- Argonne National Lab., IL (United States)
A new facility for the study of protein crystal structure using Laue diffraction has been established at the X26 beam line of the National Synchrotron Light Source (NSLS) at Brookhaven National Laboratory. The characteristics of the beam line and diffraction apparatus are described. Selected results of some of the initial experiments are discussed briefly by beam line users to illustrate the scope of the experimental program. Because the Laue method permits the recording of large data sets in a single shot, one goal in establishing this facility has been to develop the means to study time-resolved structures within protein crystals. Systems being studied include: the reactions catalyzed by trypsin; photolysis of carbonmonoxy myoglobin; and the photocycle of photoactive yellow protein.
- Research Organization:
- Brookhaven National Lab., Upton, NY (United States)
- Sponsoring Organization:
- USDOE; DOHHS; KECFOUN; USDOE, Washington, DC (United States); Department of Health and Human Services, Washington, DC (United States); Keck Foundation (United States)
- DOE Contract Number:
- AC02-76CH00016; W-31109-ENG-38
- OSTI ID:
- 6653589
- Report Number(s):
- BNL-48531; CONF-921116-23; ON: DE93009537; CNN: GM44292; GM36452; GM37684
- Resource Relation:
- Conference: 12. international conference on the application of accelerators in research and industry, Denton, TX (United States), 2-5 Nov 1992
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LIGASES
PROTEIN STRUCTURE
LYSOZYME
MYOGLOBIN
TRYPSIN
CRYSTALLOGRAPHY
NSLS
ACCELERATORS
CARBOXYLIC ACIDS
CYCLIC ACCELERATORS
ENZYMES
GLOBINS
GLYCOSYL HYDROLASES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROLASES
O-GLYCOSYL HYDROLASES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PEPTIDE HYDROLASES
PIGMENTS
PORPHYRINS
PROTEINS
RADIATION SOURCES
SERINE PROTEINASES
SYNCHROTRON RADIATION SOURCES
SYNCHROTRONS
550200* - Biochemistry