Determination of nicotine by surface-enhanced Raman scattering (SERS)

Journal Article · Tue Nov 01 04:00:00 EST 1994 · Applied Spectroscopy; (United States)

DOI:https://doi.org/10.1366/0003702944027985· OSTI ID:6651967

Barber, T E; List, M S; Haas, III, J W; Wachter, E A ^[1]

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1. Health Sciences Research Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6113 (United States)

The analytical application of surface-enhanced Raman spectroscopy (SERS) to the determination of nicotine is demonstrated. A simple spectroelectrochemical method using a copper or silver electrode as the SERS substrate has been developed, consisting of three steps: polishing a working electrode to a mirror finish; roughening the electrode in an electrolyte solution; and, finally, depositing the nicotine analyte onto the roughened electrode after immersion in a sample solution. During the reduction cycle, a large enhancement in nicotine Raman scattering is observed at the electrode surface. The intensity of the SERS signal on a silver electrode is linear with concentration from 10 to 900 ppb, with an estimated detection limit of 7 ppb. The total analysis time per sample is approximately five minutes. This procedure has been used to analyze the extract from a cigarette side-stream smoke sample (environmental tobacco smoke); the SERS results agree well with those of conventional gas chromatographic analysis.

• DOE Contract Number: AC05-84OR21400
• OSTI ID: 6651967
• Journal Information: Applied Spectroscopy; (United States), Journal Name: Applied Spectroscopy; (United States) Vol. 48:11; ISSN 0003-7028; ISSN APSPA4
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102 -- Chemical & Spectral Procedures
54 ENVIRONMENTAL SCIENCES
540120* -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (1990-)
AEROSOLS
AIR POLLUTION
ALKALOIDS
AMINES
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
AZOLES
CHEMICAL ANALYSIS
CHEMICAL COATING
COLLOIDS
DEPOSITION
DISPERSIONS
DRUGS
ELECTROCHEMICAL COATING
ENVIRONMENTAL EFFECTS
HETEROCYCLIC COMPOUNDS
LASER SPECTROSCOPY
NICOTINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASYMPATHOLYTICS
PARASYMPATHOMIMETICS
PH VALUE
POLLUTION
PYRIDINES
PYRROLES
PYRROLIDINES
QUANTITATIVE CHEMICAL ANALYSIS
RAMAN SPECTROSCOPY
RESIDUES
SMOKES
SOLS
SPECTROSCOPY
SURFACE COATING
TOBACCO SMOKES