Digital superimposition of emission tomography and X-CT images for immunoscintigraphy
In immunoscintigraphy (IS), single photon emission tomography (SPET) provides an accurate space localization of any uptake area but is affected by the lack of anatomical landmarks. The authors developed a technique where precise anatomical data are linked to the distribution of a tracer in SPET transverse slices. Twenty-two patients essentially bearing gastro-intestinal cancers were referred for IS after injection of an anti-CEA mouse monoclonal antibody (Mab) labelled with Iodine-131, SPET transverse slices were immediately analyzed. In the case of the presence of uptake areas which could correspond to a tumor site, the level of the transverse planes was marked on the patient's skin; corresponding X-CT scanner slices were performed, and using a magnetic tape transferred to the Nuclear Medicine computer system (Sopha Medical). An abdomen-like phantom was used to define the best conditions for the digital superimposition of SPET and X-CT images, using an original color scale. The method was useful for 7 patients. The uptake of the Mab was clearly confirmed in 1 case of left colon cancer and 3 cases of hepatic metastasis (HM), was ruled out in 1 case of HM and 1 case of gastric cancer, and remained doubtful in 1 case of HM associated with steatosis. They believe that this method increases the clinical specificity of IS and can be extended to any isotope study providing valuable functional information which has to be coupled with accurate morphological data.
- Research Organization:
- Institut G. Roussy and INSERM U66, Villejuif
- OSTI ID:
- 6644295
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
GASTROINTESTINAL TRACT
NEOPLASMS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
IODINE 131
DIAGNOSTIC USES
UPTAKE
LARGE INTESTINE
MONOCLONAL ANTIBODIES
LABELLING
BIOLOGICAL LOCALIZATION
DIAGNOSIS
ACCURACY
DIGESTIVE SYSTEM
DIGITAL SYSTEMS
IMAGES
INJECTION
METASTASES
MICE
MORPHOLOGY
PATIENTS
RADIOIMMUNOASSAY
RADIOISOTOPE SCANNING
SKIN
TRACER TECHNIQUES
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
IMMUNOASSAY
IMMUNOLOGY
INTAKE
INTERMEDIATE MASS NUCLEI
INTESTINES
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOASSAY
RADIOIMMUNOLOGY
RADIOISOTOPES
RODENTS
TOMOGRAPHY
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics