Susceptibility of Legionella pneumophila to three cooling tower microbicides
Journal Article
·
· Appl. Environ. Microbiol.; (United States)
OSTI ID:6642304
- Chemed Corp., St. Louis, MO
Investigation of epidemic outbreaks of Legionnaires disease by Center for Disease Control personnel has resulted in the isolation of Legionella pneumophila from water in the air-conditioning cooling towers or evaporative condensers at the site of the outbreak. It is suspected that improperly maintained open, recirculating water systems may play a role in the growth and dissemination of this pathogen. The objective of this study was to determine the antimicrobial activity of three chemically different, commercially available, cooling tower microbicides against L. pneumophila. Using two in vitro test systems, a combination of N-alkyl dimethyl benzyl ammonium chloride and bis (tri-n-butyltin) oxide was found to kill L. pneumophila at a concentration 25 times less than the minimum recommended use concentration, whereas N-alkyl 1,3-propanediamine and methylene bis(thiocyanate) were active at concentrations equal to or greater than the concentrations recommended for use by the manufacturer.
- OSTI ID:
- 6642304
- Journal Information:
- Appl. Environ. Microbiol.; (United States), Journal Name: Appl. Environ. Microbiol.; (United States) Vol. 41:1; ISSN AEMID
- Country of Publication:
- United States
- Language:
- English
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· ASHRAE
·
OSTI ID:969793
Related Subjects
550700 -- Microbiology
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AMMONIUM COMPOUNDS
AUXILIARY SYSTEMS
AUXILIARY WATER SYSTEMS
BACTERIA
BIOLOGICAL EFFECTS
CARBONIC ACID DERIVATIVES
CELL CULTURES
CHEMICAL ANALYSIS
COMPARATIVE EVALUATIONS
CONDENSER COOLING SYSTEMS
COOLING SYSTEMS
COOLING TOWERS
CULTURE MEDIA
DISINFECTANTS
DOSE-RESPONSE RELATIONSHIPS
ENERGY SYSTEMS
GERMICIDES
GROWTH
IN VITRO
INFECTIVITY
METABOLISM
MICROORGANISMS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
QUANTITATIVE CHEMICAL ANALYSIS
QUANTITY RATIO
SENSITIVITY
SURVIVAL CURVES
THIOCYANATES
TIN COMPOUNDS
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AMMONIUM COMPOUNDS
AUXILIARY SYSTEMS
AUXILIARY WATER SYSTEMS
BACTERIA
BIOLOGICAL EFFECTS
CARBONIC ACID DERIVATIVES
CELL CULTURES
CHEMICAL ANALYSIS
COMPARATIVE EVALUATIONS
CONDENSER COOLING SYSTEMS
COOLING SYSTEMS
COOLING TOWERS
CULTURE MEDIA
DISINFECTANTS
DOSE-RESPONSE RELATIONSHIPS
ENERGY SYSTEMS
GERMICIDES
GROWTH
IN VITRO
INFECTIVITY
METABOLISM
MICROORGANISMS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
QUANTITATIVE CHEMICAL ANALYSIS
QUANTITY RATIO
SENSITIVITY
SURVIVAL CURVES
THIOCYANATES
TIN COMPOUNDS