I-131 MIBG imaging of carcinoid tumors

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6639772

Blinder, R A; Feldman, J M; Coleman, R E

The potential of I-131 MIBG to image carcinoid tumors was evaluated in nine patients with pathologically proven carcinoid. Three patients with foregut carcinoid tumors (2 bronchial and one pancreatic), had abnormal urinary 5-HIAA, and one had the carcinoid syndrome. Six patients had midgut carcinoid tumors (5 ileal and 1 cecal), 5 had abnormal urinary 5-HIAA, and 4 had the carcinoid syndrome. All of the patients with midgut carcinoids had metestatic disease to the liver and/or mesentery. Two hundred microcuries of I-131 MIBG were injected intravenously and the patients were studied at 24 and 48 hours. In all patients except those with bronchial carcinoids Tc-99m sulfur colloid liver exams with computer subtraction were performed during the study. The patients with bronchial carcinoids showed no uptake in the tumors. The patient with a pancreatic carcinoid who had carcinoid syndrome demonstrated tumor uptake in hepatic metastases. Of the six patients with midgut carcinoids, 4 demonstrated MIBG uptake in tumors. One patient with mesenteric disease did not have definitive tumor uptake. A second patient with liver involvement at surgery was negative on the MIBG study. Hepatic CT and scintigraphy were negative and the patient's 5-HIAA was normal. The 4 patients with carcinoid syndrome had abnormal MIBG scans. I-131 MIBG demonstrated tumor in 4 of six patients with midgut carcinoids. MIBG was not concentrated in two carcinoids of bronchial origin. The five patients with carcinoid syndrome had positive scans. MIBG has potential as a diagnostic agent in carcinoid tumors.

• Research Organization: Duke Univ. and VA Medical Centers, Durham, NC
• OSTI ID: 6639772
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ABDOMEN
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
CARCINOMAS
CAT SCANNING
COLLOIDS
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISPERSIONS
DISTRIBUTION
DRUGS
EVALUATION
FUNCTIONS
GLANDS
HOURS LIVING RADIOISOTOPES
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIVER
LUNGS
MEDICINE
MIBG
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOCOLLOIDS
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
RESPIRATORY SYSTEM
RETENTION FUNCTIONS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
TISSUE DISTRIBUTION
TOMOGRAPHY
UPTAKE
URINARY TRACT
YEARS LIVING RADIOISOTOPES