Radiation dose calculation for Tc-99m HIDA in health and disease

Journal Article · Sun Feb 01 04:00:00 EST 1981 · J. Nucl. Med.; (United States)

OSTI ID:6638916

Brown, P H; Krishnamurthy, G T; Bobba, V V.R.; Kingston, E

Radiation dose from Tc-99m HIDA has been calculated for normal subjects and for patients with various hepatobiliary diseases classified into four groups based on serum bilirubin level. The calculation was performed on biokinetic radioactivity data from blood, urine, liver, gallbladder, and intestines, using a biological approach that included a catenary model of the digestive organs. For normal subjects the critical organs were the gallbladder and the upper and lower large intestine, with doses of 910, 300, 200 mrad/mCi, respectively. The bone marrow, ovaries, and testes received 24, 62, and 4 mrad/mCi. For Group 4 patients with severe hepatobiliary disease (bilirubin > 10 mg/dl), the critical organs were the kidney, urinary bladder, and gallbladder, with doses of 130, 110, and 100 mrad/mCi. The bone marrow, ovaries, and testes received 9, 13, and 5 mrad/mCi. Thus the critical organs and overall radiation doses to organs change between health and disease.

• Research Organization: Veterans Administration Medical Center, Portland, OR
• OSTI ID: 6638916
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:2; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETIC ACID ESTERS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILIARY TRACT
BILIRUBIN
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY
BODY FLUIDS
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DISTRIBUTION
DOSES
ESTERS
FEMALE GENITALS
GASTROINTESTINAL TRACT
GLANDS
GONADS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LIVER
MALE GENITALS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OVARIES
PATIENTS
PIGMENTS
PYRROLES
RADIATION DOSES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPONSE MODIFYING FACTORS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
TESTES
TISSUE DISTRIBUTION
URINE
USES
WASTES
YEARS LIVING RADIOISOTOPES