Twelve years' experience with irradiation as the primary treatment for breast cancer

Conference · Thu Jan 01 00:00:00 EST 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:6638593

Nobler, M P ^[1]; Venet, L

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1. Mount Sinai School of Medicine, New York, NY

Ninety patients received comprehensive, high-dose, supervoltage teletherapy as the primary treatment for carcinoma of the breast, following a biopsy or a segmental resection. The tumor doses delivered to the breast ranged between 5600 and 7000 rad in six to nine weeks; the draining lymph nodes received tumor doses of 5000 to 7000 rad in six to eight weeks. In five cases, Iridium-192 implants were employed to boost the radiation dose to the breast, and in seven instances a toilette mastectomy was performed for residual cancer. Satisfactory local control and cosmetic results were achieved in 86 patients. The patients were followed for 2 1/2 to 12 1/2 years. The local control rates were: Stage I, 100%, Stage II, 95%; Stage III, 100%; Stave IV (M-0), 89%; Stave IV (M-1), 100%. The overall disease-free survival figures were: Stage I, 85%; Stage II, 48%; Stage III, 50%; and Stage IV (M-0), 29%. We feel that this approach to the initial management of breast cancer is a practical, useful, and successful substitute for mastectomy when medical or surgical contraindications exist, or when the patient refuses a mastectomy.

• OSTI ID: 6638593
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 7:1; Conference: 21. annual meeting of the American Society of Therapeutic Radiologists, New Orleans, LA, USA, 23 Oct 1979
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOMAS
DELAYED RADIATION EFFECTS
MAMMARY GLANDS
TUMOR CELLS
RADIOSENSITIVITY
COBALT 60
DOSE-RESPONSE RELATIONSHIPS
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BIOLOGICAL RADIATION EFFECTS
BODY
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DAYS LIVING RADIOISOTOPES
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ELECTRON CAPTURE RADIOISOTOPES
GLANDS
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MEDICINE
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NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIATION EFFECTS
RADIATION SOURCES
RADIOISOTOPES
RADIOLOGY
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YEARS LIVING RADIOISOTOPES
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