Behavioral evaluation of sensory irritation evoked by ammonia
Journal Article
·
· Toxicol. Appl. Pharmacol.; (United States)
Mice will respond to escape from ammonia vapor, a prototypical airborne chemical irritant. Nose poking at a conical sensor is maintained if it terminates the delivery of ammonia to a small exposure chamber and produces a facial shower of clean, humidified air from the sensor. The duration of exposure to ammonia tolerated decreased as ammonia concentration increased (0.0 to 0.2%). The percentage of ammonia deliveries terminated by a response also increased as concentration increased. The behavior did not result from a general increase in activity. Thus, ammonia vapor delivery is an effective negative reinforcer for the mouse. This technique can help evaluate the aversive properties of atmospheric contaminants.
- Research Organization:
- Univ. of Rochester School of Medicine, NY
- OSTI ID:
- 6637267
- Journal Information:
- Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 50; ISSN TXAPA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Determinants of irritant termination behavior
Behavioral evaluation of the irritating properties of ozone
Sensory irritation and incapacitation evoked by thermal decomposition products of polymers and comparisons with known sensory irritants
Journal Article
·
Wed Dec 31 23:00:00 EST 1980
· Toxicol. Appl. Pharmacol.; (United States)
·
OSTI ID:5236606
Behavioral evaluation of the irritating properties of ozone
Journal Article
·
Wed May 01 00:00:00 EDT 1985
· Toxicol. Appl. Pharmacol.; (United States)
·
OSTI ID:6177748
Sensory irritation and incapacitation evoked by thermal decomposition products of polymers and comparisons with known sensory irritants
Journal Article
·
Sat Dec 31 23:00:00 EST 1977
· Arch. Environ. Health; (United States)
·
OSTI ID:6799985
Related Subjects
550100 -- Behavioral Biology
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
AMMONIA
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BODY
DOSE-RESPONSE RELATIONSHIPS
EXPOSURE CHAMBERS
FLUIDS
GASES
HYDRIDES
HYDROGEN COMPOUNDS
MAMMALS
MICE
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
ORGANS
POLLUTION
RODENTS
SENSE ORGANS
SENSITIVITY
VAPORS
VERTEBRATES
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
AMMONIA
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BODY
DOSE-RESPONSE RELATIONSHIPS
EXPOSURE CHAMBERS
FLUIDS
GASES
HYDRIDES
HYDROGEN COMPOUNDS
MAMMALS
MICE
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
ORGANS
POLLUTION
RODENTS
SENSE ORGANS
SENSITIVITY
VAPORS
VERTEBRATES