Mechanisms of recovery from aphasia: evidence from serial xenon 133 cerebral blood flow studies

Journal Article · Fri Jun 01 00:00:00 EDT 1984 · Ann. Neurol.; (United States)

DOI:https://doi.org/10.1002/ana.410150604· OSTI ID:6630474

Knopman, D S; Rubens, A B; Selnes, O A; Klassen, A C; Meyer, M W

In 21 patients who suffered aphasia resulting from left hemisphere ischemic infarction, the xenon 133 inhalation cerebral blood flow technique was used to measure cerebral blood flow within 3 months and 5 to 12 months after stroke. In addition to baseline measurements, cerebral blood flow measurements were also carried out while the patients were performing purposeful listening. In patients with incomplete recovery of comprehension and left posterior temporal-inferior parietal lesions, greater cerebral blood flow occurred with listening in the right inferior frontal region in the late studies than in the early studies. In patients with nearly complete recovery of comprehension and without left posterior temporal-inferior parietal lesions, early listening studies showed diffuse right hemisphere increases in cerebral blood flow. Later listening studies in this latter patient group showed greater cerebral blood flow in the left posterior temporal-inferior parietal region. The study provides evidence for participation of the right hemisphere in language comprehension in recovering aphasics, and for later return of function in left hemisphere regions that may have been functionally impaired early during recovery.

• Research Organization: Department of Neurology, University of Minnesota, Minneapolis
• OSTI ID: 6630474
• Journal Information: Ann. Neurol.; (United States), Vol. 15:6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CEREBRUM
BLOOD FLOW
VASCULAR DISEASES
BIOLOGICAL RECOVERY
BEHAVIOR
PATIENTS
TRACER TECHNIQUES
XENON 133
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
RECOVERY
XENON ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics