Pharyngeal wall cancer; an analysis of treatment results complications and patterns of failure

Journal Article · Sun Jan 01 00:00:00 EST 1978 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(78)90179-7· OSTI ID:6630253

Marks, J E ^[1]; Freeman, R B; Lee, F; Ogura, J H

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1. Edward Mallinckrodt Inst. of Radiology, St. Louis

Fifty-one patients who were treated for pharyngeal wall cancer during the 10-year period, 1964 to 1974, were reviewed retrospectively Of the 51 patients, 29 were treated with low-dose preoperative radiation and a variety of surgical procedures, 13 were treated with high doses of radiation, and the remaining nine were treated by miscellaneous means. Actuarial 3-year survival was 17% for all patients and decreased progressively with advancing T and N stages. Survival did not differ for the two major treatment groups, but major complications including pharyngocutaneous fistulae (31%), carotid rupture (14%), and operative mortality(14%) were significantly greater for the preoperative radiation--surgery group than for the radiation-alone group. Tumor and regional nodes were controlled in 22 of 51 (43%) patients, 2 of them after surgical salvage of local failure. Control of primary tumor and regional nodes lessened progressively with advancing size of the primary tumor but not with advancing nodal stage. Twenty-nine of 33 relapses (88%) occurred within 1 year and involved the primary site in 49%, the neck in 33%, and distant sites in 14%. Two primary cancers occurred in 11 patients (22%). The major cause of death was tumor, with a few deaths resulting from intercurrent disease, complications, and other cancers.

• OSTI ID: 6630253
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 4:7-8
• Country of Publication: United States
• Language: English

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