Arrest of irradiated G1, S, or G2 cells at mitosis using nocodazole promotes repair of potentially lethal damage
Journal Article
·
· Radiat. Res.; (United States)
The ability of synchronized Ehrlich ascites tumor cells, irradiated in G1, S, and G2 phases, to repair potentially lethal damage when arrested at mitosis by using 0.4 ..mu..g/ml nocodazole, a specific inhibitor of microtubule polymerization, has been studied. Cells irradiated in these phases were found to repair potentially lethal damage at mitosis. The extent of this repair was similar to that observed for cells irradiated at the same stages in the cell cycle but allowed to repair potentially lethal damage by incubating in balanced salt solution for 6 hr after X irradiation.
- Research Organization:
- Universitaet Frankfurt, West Germany
- OSTI ID:
- 6629306
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 99:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Evidence that repair and expression of potentially lethal damage cause the variations in cell survival after x irradiation observed through the cell cycle in Ehrlich ascites tumor cells
RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
Conditions supporting repair of potentially lethal damage cause a significant reduction of ultraviolet light-induced division delay in synchronized and plateau-phase Ehrlich ascites tumor cells
Journal Article
·
Fri Jul 01 00:00:00 EDT 1983
· Radiat. Res.; (United States)
·
OSTI ID:5816858
RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
Journal Article
·
Fri Jul 15 00:00:00 EDT 1988
· Science (Washington, D.C.); (United States)
·
OSTI ID:6823697
Conditions supporting repair of potentially lethal damage cause a significant reduction of ultraviolet light-induced division delay in synchronized and plateau-phase Ehrlich ascites tumor cells
Journal Article
·
Wed Sep 01 00:00:00 EDT 1982
· Radiat. Res.; (United States)
·
OSTI ID:6709094
Related Subjects
550300 -- Cytology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIMITOTIC DRUGS
ASCITES TUMOR CELLS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL CULTURES
CELL CYCLE
CELL DIVISION
CELL KILLING
DRUGS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MITOSIS
MITOTIC DELAY
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
SURVIVAL CURVES
SYNCHRONOUS CULTURES
TUMOR CELLS
X RADIATION
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIMITOTIC DRUGS
ASCITES TUMOR CELLS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL CULTURES
CELL CYCLE
CELL DIVISION
CELL KILLING
DRUGS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MITOSIS
MITOTIC DELAY
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
SURVIVAL CURVES
SYNCHRONOUS CULTURES
TUMOR CELLS
X RADIATION