Malignant fibrous histiocytoma developing in irradiated sacral chordoma

Journal Article · Fri Jun 15 04:00:00 EDT 1984 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19840615)53:12<2661::AID-CNCR2820531215>3.0.CO;2-6· OSTI ID:6628880

Halpern, J; Kopolovic, J; Catane, R

Malignant fibrous histiocytoma (MFH), arising at the site of a sacral chordoma 8 years after massive radiotherapy, is described. Initially, the patient received 7000 rad to the sacral area and, on recurrence, 5 years later, an additional 4000 rad. Two years later, a sacral mass was noted again. Biopsy then revealed MFH; chest x-ray showed multiple lung metastases. A combination chemotherapy, consisting of cyclophosphamide, vincristine, adriamycin (doxorubicin), and DTIC, resulted in a 6 month partial response. Subsequently, the patient died because of progressive metastatic disease. At autopsy, 8 years after diagnosis, both the sacral lesion and the lung metastases proved to be MFH, and no residual chordoma was found.

• Research Organization: Hadassah Univ. Hospital, Jerusalem, Israel
• OSTI ID: 6628880
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 53:12; ISSN CANCA
• Country of Publication: United States
• Language: English

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